Destroy this temple and in three days I will raise it up. It seems to me that Jesus meant the Jews in this episode to stand for sensual men and those desirous of carnal and sensual things. These Jews were angry at his expulsion of the people who were turning his Father’s house into a market. So they asked for a sign to justify these actions, a sign that would show that the Word of God, whom they refused to accept, was acting rightly. The Savior’s reply combines a statement about the temple with a prophecy about his own body, for in answer to their question: What sign can you give to justify your conduct? he says: Destroy this temple and in three days I will raise it up.
From a commentary on John by Origen, priest